Job Description

Job Title: Principal Mechanical Engineer II, Early Research and Development

Location: Santa Clara, CA 95050

⏳ Duration: 6 Months (Possibility of Extension)

About the Role

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.

We are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.

Our Systems Technology Group is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows.

Core Responsibilities

• You will lead the end-to-end mechanical design and development of mechanical sub-systems including electro-mechanical, pneumatic, fluidic, and thermal components.
• You will collaborate with engineers from other disciplines (electrical, consumables, materials) to define and manage all critical technical interfaces for your module.
• You will develop novel mechanisms for automated reagent and flow cell loading, clamping, and sealing, ensuring reliability over repeated use.
• You will architect and design thermal control systems, including the specification and integration of heating/cooling elements, sensors, condensation control, and heat management.
• You will partner with internal and external simulation experts to guide and validate CFD, thermal, and optical models, using empirical data to refine designs.
• You will serve as the primary technical expert for your sub-system during integration, verification, and troubleshooting activities, working directly with the Systems Integration team.
• You will lead cross-functional design reviews, driving alignment and resolving technical trade-offs between mechanical design, consumables, materials, and assay requirements.
• You will drive the technical execution for sub-systems, manage timelines for your design deliverables, and contribute to the overall project plan.
• You will create and maintain all design documentation for your sub-systems, including detailed CAD models, drawings, and specifications.
• You will contribute to the technical strategy for the future integrated system, providing data-driven recommendations on architecture and technology choices based on your sub-system's performance.
• You will present technical progress, data, and design trade-offs to the broader project team and key stakeholders, clearly articulating the rationale and impact of engineering decisions.

Required Qualifications

• You have a PhD in Mechanical Engineering, Bioengineering, or a related discipline with at least 3 years of relevant industry experience; or a Master's degree with at least 4 years; or a Bachelor's degree with 7+ years of relevant experience.
• You have demonstrated deep, hands-on expertise in the design, development, and testing of complex mechanical, electro-mechanical, and pneumatic systems, preferably for life science or diagnostic instrumentation.
• You have demonstrated hands-on expertise in thermal management and the design of precision temperature control systems.
• You have experience developing fluidics systems and their interfaces including pumps, valves, tubing, sensors, and material selection.
• You possess strong proficiency in 3D CAD software (e.g., SolidWorks).
• You have expertise designing components for a variety of manufacturing processes (machining, injection molding, 3D printing).
• You are a creative and resourceful problem-solver, with the ability to troubleshoot complex issues at the interface of hardware, software, and chemistry.
• You are proficient with common machine shop tools, as well as test and measurement equipment; proficient with rapid prototyping technology such as 3D printers, laser cutters, CNC mills/lathes, etc.
• You have a demonstrated level of proficiency with Python, LabVIEW, or similar tools for device control and data acquisition.

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